The Rho-associated kinase inhibitors Y27632 and fasudil promote microglial migration in the spinal cord via the ERK signaling pathway

The Rho-associated kinase inhibitors Y27632 and fasudil promote microglial migration in the spinal cord via the ERK signaling pathway

Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system. Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase (ERK) signaling pathway...

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Bibliographic Details
Main Authors: Pei-Cai Fu, Rong-Hua Tang, Zhi-Yuan Yu, Min-Jie Xie, Wei Wang, Xiang Luo
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; spinal cord injury; microglia; ROCK; Y27632; fasudil; migration; morphology; ERK; U0126; in-cell western blot assay; Transwell chambers; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=4;spage=677;epage=683;aulast=Fu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=4;spage=677;epage=683;aulast=Fu

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