An Optically Pure Apogossypolone Derivative As Potent Pan-active Inhibitor of Anti-apoptotic Bcl-2 Family Proteins

An Optically Pure Apogossypolone Derivative As Potent Pan-active Inhibitor of Anti-apoptotic Bcl-2 Family Proteins

Our focus in the past several years has been on the identification of novel and effective pan-Bcl-2 antagonists. We have recently reported a series of Apogossypolone (ApoG2) derivatives, resulting in the chiral compound (+/-) BI97D6. We report here the synthesis and evaluation on its optically pure...

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Bibliographic Details
Main Authors: Jun eWei, John L Stebbins, Shinichi eKitada, Rupesh eDash, Dayong eZhai, William J Placzek, Bainan eWu, Michele F Rega, Ziming eZhang, Elisa eBarile, Li eYang, Russell eDahl, Paul B. Fisher, John C Reed, Maurizio ePellecchia
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-09-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
Cancer
5
5’ Apogossypolone derivatives
Anti-apoptotic Bcl-2
Apogossypolone
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00028/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00028/full

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