Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs

Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs

Abstract Increasing evidence suggest that the glucose-lowering drug metformin exerts a valuable anti-senescence role. The ability of metformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested. MicroRNA isoforms (isomiRs) are distinct variations of miRNA sequences, harbo...

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Bibliographic Details
Main Authors: Angelica Giuliani, Eric Londin, Manuela Ferracin, Emanuela Mensà, Francesco Prattichizzo, Deborah Ramini, Fiorella Marcheselli, Rina Recchioni, Maria Rita Rippo, Massimiliano Bonafè, Isidore Rigoutsos, Fabiola Olivieri, Jacopo Sabbatinelli
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78871-5

Internet

https://doi.org/10.1038/s41598-020-78871-5

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