Paxilline Prevents the Onset of Myotonic Stiffness in Pharmacologically Induced Myotonia: A Preclinical Investigation

Paxilline Prevents the Onset of Myotonic Stiffness in Pharmacologically Induced Myotonia: A Preclinical Investigation

Reduced Cl− conductance causes inhibited muscle relaxation after forceful voluntary contraction due to muscle membrane hyperexcitability. This represents the pathomechanism of myotonia congenita. Due to the prevailing data suggesting that an increased potassium level is a main contributor, we studie...

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Bibliographic Details
Main Authors: Kerstin Hoppe, Tina Sartorius, Sunisa Chaiklieng, Georg Wietzorrek, Peter Ruth, Karin Jurkat-Rott, Scott Wearing, Frank Lehmann-Horn, Werner Klingler
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
paxilline
NS1608
repetitive firing
myotonia congenita
muscle disease
BK channel
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.533946/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.533946/full

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