The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology

The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology

Age-related macular degeneration (AMD) is a mounting cause of loss of sight in the elderly in the developed countries, a trend enhanced by the continual ageing of the population. AMD is a multifactorial and only partly understood, malady. Unfortunately, there is no effective treatment for most AMD p...

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Bibliographic Details
Main Authors: Juha M. T. Hyttinen, Ram Kannan, Szabolcs Felszeghy, Minna Niittykoski, Antero Salminen, Kai Kaarniranta
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
age-related macular degeneration
epithelial-to-mesenchymal transition
hypoxia
nuclear factor erythroid 2-related factor
oxidative stress
reactive oxygen species
retinal pigment epithelium
Online Access:https://www.mdpi.com/1422-0067/20/22/5800

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https://www.mdpi.com/1422-0067/20/22/5800

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