Sickling-preventive effects of rutin is associated with modulation of deoxygenated haemoglobin, 2,3-bisphosphoglycerate mutase, redox status and alteration of functional chemistry in sickle erythrocytes

Sickling-preventive effects of rutin is associated with modulation of deoxygenated haemoglobin, 2,3-bisphosphoglycerate mutase, redox status and alteration of functional chemistry in sickle erythrocytes

Sickle cell anaemia is a hereditary disease branded by an upsurge in generation of ROS, irregular iron release and little or no antioxidant activity which can lead to cellular injuries due to oxidative stress resulting in severe symptoms including anaemia and pain. The disease is caused by a mutated...

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Bibliographic Details
Main Authors: Aliyu Muhammad, Aliyu Dahiru Waziri, Gilead Ebiegberi Forcados, Babangida Sanusi, Hadiza Sani, Ibrahim Malami, Ibrahim Babangida Abubakar, Habeebah Yahya Oluwatoyin, Otaru Abdulrasheed Adinoyi, Hafsat Abdullahi Mohammed
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Heliyon
Subjects:
Cell biology
Rutin
Antisickling
Redox
Erythrocytes
Haemoglobin
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844019319905

Internet

http://www.sciencedirect.com/science/article/pii/S2405844019319905

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