Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice

Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice

Pharmacological blockade of the cannabinoid type 1 receptor, a G protein-coupled receptor expressed in the central nervous system and various peripheral tissues, reverses diet-induced obesity and dyslipidemia through the reduction of food intake and altered nutrient partitioning. This strategy is be...

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Bibliographic Details
Main Authors: Robin van Eenige, Zhixiong Ying, Lauren Tambyrajah, Amanda C.M. Pronk, Niek Blomberg, Martin Giera, Yanan Wang, Tamer Coskun, Mario van der Stelt, Patrick C.N. Rensen, Sander Kooijman
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
adipose tissue
atherosclerosis
bile acids and salts/metabolism
cannabinoid receptor type 1
cardiovascular disease
drug therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227521000523

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http://www.sciencedirect.com/science/article/pii/S0022227521000523

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