A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use

A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use

Abstract Background It has become increasingly apparent that the trophectoderm (TE) at blastocyst stage is much more mosaic than has been appreciated. Whether preimplantation genetic screening (PGS), utilizing a single TE biopsy (TEB), can reliably determine embryo ploidy has, therefore, increasingl...

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Bibliographic Details
Main Authors: Norbert Gleicher, Jacob Metzger, Gist Croft, Vitaly A. Kushnir, David F. Albertini, David H Barad
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Reproductive Biology and Endocrinology
Subjects:
Premplantation genetic screening
Trophectoderm biopsy
Mathematical model
In vitro fertilization
Online Access:http://link.springer.com/article/10.1186/s12958-017-0251-8

Internet

http://link.springer.com/article/10.1186/s12958-017-0251-8

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