Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

Objective: Glucagon-like peptide-1 (GLP-1) neurons in the hindbrain densely innervate the dorsomedial hypothalamus (DMH), a nucleus strongly implicated in body weight regulation and the sympathetic control of brown adipose tissue (BAT) thermogenesis. Therefore, DMH GLP-1 receptors (GLP-1R) are well...

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Bibliographic Details
Main Authors: Shin J. Lee, Graciela Sanchez-Watts, Jean-Philippe Krieger, Angelica Pignalosa, Puck N. Norell, Alyssa Cortella, Klaus G. Pettersen, Dubravka Vrdoljak, Matthew R. Hayes, Scott Kanoski, Wolfgang Langhans, Alan G. Watts
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877818301431

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http://www.sciencedirect.com/science/article/pii/S2212877818301431

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