Electrical stimulation of the superior sagittal sinus suppresses A-type K+ currents and increases P/Q- and T-type Ca2+ currents in rat trigeminal ganglion neurons

Electrical stimulation of the superior sagittal sinus suppresses A-type K+ currents and increases P/Q- and T-type Ca2+ currents in rat trigeminal ganglion neurons

Abstract Background Migraine is a debilitating neurological disorder involving abnormal trigeminovascular activation and sensitization. However, the underlying cellular and molecular mechanisms remain unclear. Methods A rat model of conscious migraine was established through the electrical stimulati...

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Bibliographic Details
Main Authors: Junping Cao, Yuan Zhang, Lei Wu, Lidong Shan, Yufang Sun, Xinghong Jiang, Jin Tao
Format: Article
Language:English
Published: BMC 2019-08-01
Series:The Journal of Headache and Pain
Subjects:
Migraine
Trigeminal ganglion neurons
Neuronal excitability
A-type K+ channels
T-type Ca2+ channels
Online Access:http://link.springer.com/article/10.1186/s10194-019-1037-5

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http://link.springer.com/article/10.1186/s10194-019-1037-5

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