Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice.

Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice.

Insulin-like growth factor-I (IGF-I) deficiency causes growth delay, and IGF-I has been shown to partially mediate bone anabolism by parathyroid hormone (PTH). PTH-related protein (PTHrP) is abundant in bone, and has osteogenic features by poorly defined mechanisms. We here examined the capacity of...

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Bibliographic Details
Main Authors: Lourdes Rodríguez-de la Rosa, Ana López-Herradón, Sergio Portal-Núñez, Silvia Murillo-Cuesta, Daniel Lozano, Rafael Cediel, Isabel Varela-Nieto, Pedro Esbrit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3913635?pdf=render

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http://europepmc.org/articles/PMC3913635?pdf=render

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