Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells via the Fas/Fas Ligand Pathway.

Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells via the Fas/Fas Ligand Pathway.

Osteoprotegerin (OPG) is known to inhibit differentiation and activation of osteoclasts (OCs) by functioning as a decoy receptor blocking interactions between RANK and RANKL. However, the exact role of OPG in the survival/apoptosis of OCs remains unclear. OPG caused increased rates of apoptosis of b...

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Bibliographic Details
Main Authors: Wei Liu, Chao Xu, Hongyan Zhao, Pengpeng Xia, Ruilong Song, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Yan Yuan, Zongping Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4646684?pdf=render

Internet

http://europepmc.org/articles/PMC4646684?pdf=render

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