Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome

Transgenic mice overexpressing Dyrk1A (TgDyrk1A), a Down syndrome (DS) candidate gene, exhibit motor and cognitive alterations similar to those observed in DS individuals. To gain new insights into the molecular consequences of Dyrk1A overexpression underlying TgDyrk1A and possibly DS motor phenotyp...

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Bibliographic Details
Main Authors: X. Altafaj, J. Ortiz-Abalia, M. Fernández, M.C. Potier, J. Laffaire, N. Andreu, M. Dierssen, C. González-García, V. Ceña, E. Martí, C. Fillat
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Neurobiology of Disease
Subjects:
Down syndrome
DYRK1A
NMDA receptors
Cerebellum
Motor phenotype
Murine models
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001848

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http://www.sciencedirect.com/science/article/pii/S0969996108001848

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