Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA

Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA

Changes in striatal cholinergic interneuron (ChI) activity are thought to contribute to Parkinson’s disease pathophysiology and dyskinesia from chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment, but the physiological basis of these changes is unknown. We find that dopamine lesion decreases the...

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Bibliographic Details
Main Authors: Se Joon Choi, Thong C Ma, Yunmin Ding, Timothy Cheung, Neal Joshi, David Sulzer, Eugene V Mosharov, Un Jung Kang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
parkinson's disease
striatum
HCN
SK
spontaneous firing
electrophysiology
Online Access:https://elifesciences.org/articles/56920

Internet

https://elifesciences.org/articles/56920

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