Cyclin-Dependent Kinase Inhibitors in Hematological Malignancies—Current Understanding, (Pre-)Clinical Application and Promising Approaches

Cyclin-Dependent Kinase Inhibitors in Hematological Malignancies—Current Understanding, (Pre-)Clinical Application and Promising Approaches

Genetically altered stem or progenitor cells feature gross chromosomal abnormalities, inducing modified ability of self-renewal and abnormal hematopoiesis. Cyclin-dependent kinases (CDK) regulate cell cycle progression, transcription, DNA repair and are aberrantly expressed in hematopoietic malignan...

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Bibliographic Details
Main Authors: Anna Richter, Nina Schoenwaelder, Sina Sender, Christian Junghanss, Claudia Maletzki
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
CDK4/6 inhibitors
predictive biomarker
mechanisms of resistance
pharmacological inhibition
combination strategies
Online Access:https://www.mdpi.com/2072-6694/13/10/2497

Internet

https://www.mdpi.com/2072-6694/13/10/2497

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