Computational Aminoacyl-tRNA Synthetase Library Design for Photocaged Tyrosine

Computational Aminoacyl-tRNA Synthetase Library Design for Photocaged Tyrosine

Engineering aminoacyl-tRNA synthetases (aaRSs) provides access to the ribosomal incorporation of noncanonical amino acids via genetic code expansion. Conventional targeted mutagenesis libraries with 5–7 positions randomized cover only marginal fractions of the vast sequence space formed by...

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Bibliographic Details
Main Authors: Tobias Baumann, Matthias Hauf, Florian Richter, Suki Albers, Andreas Möglich, Zoya Ignatova, Nediljko Budisa
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
enzyme design
noncanonical amino acids
protein modification
directed evolution
mutagenesis
gene libraries
genetic code expansion
unnatural amino acids
protein engineering
Online Access:https://www.mdpi.com/1422-0067/20/9/2343

Internet

https://www.mdpi.com/1422-0067/20/9/2343

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