Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

It is of utmost importance to decipher the role of chronic exposure to low doses of environmental carcinogens on breast cancer progression. The early-transformed triple-negative human mammary MCF10AT1 cells were chronically (60 days) exposed to low doses (10−10 M) of Benzo[a]pyrene (B[a]P), a genoto...

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Bibliographic Details
Main Authors: Caterina F. Donini, Myriam El Helou, Anne Wierinckx, Balázs Győrffy, Sophie Aires, Aurélie Escande, Séverine Croze, Philippe Clezardin, Joël Lachuer, Mona Diab-Assaf, Sandra E. Ghayad, Béatrice Fervers, Vincent Cavaillès, Véronique Maguer-Satta, Pascale A. Cohen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
environmental factors
Benzo[a]pyrene
Bisphenol-A
breast cancer
tumor progression
AhR
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00712/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00712/full

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