A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

Robust biomarkers of aging have been developed from DNA methylation in humans and more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a model with unique physical, physiological, and biochemical advantages—by incorporating behavioral data, unsupervised machine learn...

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Bibliographic Details
Main Authors: Morgan Levine, Ross A McDevitt, Margarita Meer, Kathy Perdue, Andrea Di Francesco, Theresa Meade, Colin Farrell, Kyra Thrush, Meng Wang, Christopher Dunn, Matteo Pellegrini, Rafael de Cabo, Luigi Ferrucci
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
epigenetic clock
DNA methylation
caloric restriction
biological age
Online Access:https://elifesciences.org/articles/59201

Internet

https://elifesciences.org/articles/59201

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