Subtype Specific Differences in NS5A Domain II Reveals Involvement of Proline at Position 310 in Cyclosporine Susceptibility of Hepatitis C Virus

Subtype Specific Differences in NS5A Domain II Reveals Involvement of Proline at Position 310 in Cyclosporine Susceptibility of Hepatitis C Virus

Hepatitis C virus (HCV) is susceptible to cyclosporine (CsA) and other cyclophilin (CypA) inhibitors, but the genetic basis of susceptibility is controversial. Whether genetic variation in NS5A alters cell culture susceptibility of HCV to CypA inhibition is unclear. We constructed replicons containi...

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Bibliographic Details
Main Authors: Israr-ul H. Ansari, Rob Striker
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Viruses
Subjects:
Hepatitis C virus
cyclosporine
cyclophilin
susceptibility
Online Access:http://www.mdpi.com/1999-4915/4/12/3303

Internet

http://www.mdpi.com/1999-4915/4/12/3303

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