Gut microbial diversity, inflammation, and oxidative stress are associated with tacrolimus dosing requirements early after heart transplantation.

Gut microbial diversity, inflammation, and oxidative stress are associated with tacrolimus dosing requirements early after heart transplantation.

INTRODUCTION:Effective tacrolimus (TAC) dosing is hampered by complex pharmacokinetics and significant patient variability. The gut microbiome, a key mediator of endotoxemia, inflammation and oxidative stress in advanced heart failure (HF) patients, is a possible contributor to interindividual varia...

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Bibliographic Details
Main Authors: Douglas L Jennings, Bruno Bohn, Amelia Zuver, Duygu Onat, Maureen Gaine, Eugene Royzman, Jonathan Hupf, Danielle Brunjes, Farhana Latif, Susan Restaino, Arthur R Garan, Veli K Topkara, Hiroo Takayama, Koji Takeda, Yoshifumi Naka, Maryjane Farr, Renu Nandakumar, Anne-Catrin Uhlemann, Paolo C Colombo, Ryan T Demmer, Melana Yuzefpolskaya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0233646

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https://doi.org/10.1371/journal.pone.0233646

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