Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures

Innate immunity mediated by microglia appears to play a crucial role in initiating and propagating seizure-induced inflammatory responses. To address the role of activated microglia in the pathogenesis of childhood epilepsy, we first examined the time course of microglia activation following kainic...

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Bibliographic Details
Main Authors: Jayne Abraham, Patrick D. Fox, Carlo Condello, Alyssa Bartolini, Sookyong Koh
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000484