Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses.

Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses.

CD5 is a lymphoid-specific transmembrane glycoprotein constitutively expressed on thymocytes and mature T and B1a lymphocytes. Current data support the view that CD5 is a negative regulator of antigen-specific receptor-mediated signaling in these cells, and that this would likely be achieved through...

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Main Authors: Rafael Fenutría, Vanesa G Martinez, Inês Simões, Jorge Postigo, Victor Gil, Mario Martínez-Florensa, Jordi Sintes, Rodrigo Naves, Kevin S Cashman, José Alberola-Ila, Manel Ramos-Casals, Gloria Soldevila, Chander Raman, Jesús Merino, Ramón Merino, Pablo Engel, Francisco Lozano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3893160?pdf=render

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http://europepmc.org/articles/PMC3893160?pdf=render

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