Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

The rTg4510 mosue line has a tauopathy-like phenotype which is attributed to overexpression of human tau in the frontal cortex. Here the authors identify potential confounding genetic factors that could contribute to the phenotype.

Bibliographic Details
Main Authors: Julia Gamache, Kellie Benzow, Colleen Forster, Lisa Kemper, Chris Hlynialuk, Eva Furrow, Karen H. Ashe, Michael D. Koob
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10428-1