Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice
The rTg4510 mosue line has a tauopathy-like phenotype which is attributed to overexpression of human tau in the frontal cortex. Here the authors identify potential confounding genetic factors that could contribute to the phenotype.
Main Authors: | Julia Gamache, Kellie Benzow, Colleen Forster, Lisa Kemper, Chris Hlynialuk, Eva Furrow, Karen H. Ashe, Michael D. Koob |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-10428-1 |
Similar Items
-
Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
by: Katherine J Kopeikina, et al.
Published: (2013-01-01) -
Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.
by: Xiaohai Wang, et al.
Published: (2018-01-01) -
In Vivo Tau Imaging for a Diagnostic Platform of Tauopathy Using the rTg4510 Mouse Line
by: Naruhiko Sahara, et al.
Published: (2017-12-01) -
Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy
by: Thomas Blackmore, et al.
Published: (2017-09-01) -
Altered Brain Metabolome Is Associated with Memory Impairment in the rTg4510 Mouse Model of Tauopathy
by: Mireia Tondo, et al.
Published: (2020-02-01)