UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes

UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes

The enzyme serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the first committed and rate-limiting step in sphingolipid synthesis, is up-regulated in the epidermis as part of the homeostatic repair in response to permeability barrier perturbation. Moreover, UVB exposure, which also per...

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Bibliographic Details
Main Authors: Angela M. Farrell, Yoshikazu Uchida, M. Marek Nagiec, Ian R. Harris, Robert C. Dickson, Peter M. Elias, Walter M. Holleran
Format: Article
Language:English
Published: Elsevier 1998-10-01
Series:Journal of Lipid Research
Subjects:
barrier
ceramides
epidermis
keratinocytes
skin
sphingolipids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520325013

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http://www.sciencedirect.com/science/article/pii/S0022227520325013

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