A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways.

A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways.

Invasion of human erythrocytes is essential for Plasmodium falciparum parasite survival and pathogenesis, and is also a complex phenotype. While some later steps in invasion appear to be invariant and essential, the earlier steps of recognition are controlled by a series of redundant, and only parti...

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Bibliographic Details
Main Authors: Susana Campino, Alejandro Marin-Menendez, Alison Kemp, Nadia Cross, Laura Drought, Thomas D Otto, Ernest Diez Benavente, Matt Ravenhall, Frank Schwach, Gareth Girling, Magnus Manske, Michel Theron, Kelda Gould, Eleanor Drury, Taane G Clark, Dominic P Kwiatkowski, Alena Pance, Julian C Rayner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007436

Internet

https://doi.org/10.1371/journal.ppat.1007436

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