Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6

Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6

SIRT6 plays essential roles in metabolism, tumor suppression, and DNA repair through the deacetylation of histone substrates. Here the authors use biophysical methods to investigate the molecular basis for SIRT6 interaction with the nucleosome core particle.

Bibliographic Details
Main Authors: Wallace H. Liu, Jie Zheng, Jessica L. Feldman, Mark A. Klein, Vyacheslav I. Kuznetsov, Craig L. Peterson, Patrick R. Griffin, John M. Denu
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19018-y

Internet

https://doi.org/10.1038/s41467-020-19018-y

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