Porcine Circovirus Type 2 ORF5 Protein Induces Autophagy to Promote Viral Replication via the PERK-eIF2α-ATF4 and mTOR-ERK1/2-AMPK Signaling Pathways in PK-15 Cells

Porcine Circovirus Type 2 ORF5 Protein Induces Autophagy to Promote Viral Replication via the PERK-eIF2α-ATF4 and mTOR-ERK1/2-AMPK Signaling Pathways in PK-15 Cells

Porcine circovirus type 2 (PCV2) is the primary causative agent that causing porcine circovirus-associated disease (PCVAD). The open reading frame 5 (ORF5) protein is a newly discovered non-structural protein in PCV2, which the function in viral pathogenesis remains unknown. The aim of this study wa...

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Bibliographic Details
Main Authors: Jiangman Lv, Yanfen Jiang, Quanwen Feng, Zhixin Fan, Ying Sun, Panpan Xu, Yufeng Hou, Xiuping Zhang, Yuxin Fan, Xingang Xu, Yanming Zhang, Kangkang Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Microbiology
Subjects:
autophagy
ORF5 protein
PK-15 Cell
Porcine circovirus 2
virus replication
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00320/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00320/full

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