SUV39H1 downregulation induces deheterochromatinization of satellite regions and senescence after exposure to ionizing radiation

While the majority of cancer patients are exposed to ionizing radiation during diagnostic and therapeutic procedures, age-dependent differences in radiation sensitivity are not yet well understood. Radiation sensitivity is characterized by the appearance of side effects to radiation therapy, such as...

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Bibliographic Details
Main Authors: Corinne eSidler, Dongping eLi, Bo eWang, Igor eKovalchuk, Olga eKovalchuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00411/full