Optimizing neuromelanin contrast in the substantia nigra and locus coeruleus using a magnetization transfer contrast prepared 3D gradient recalled echo sequence

Optimizing neuromelanin contrast in the substantia nigra and locus coeruleus using a magnetization transfer contrast prepared 3D gradient recalled echo sequence

Neuromelanin (NM) loss in the substantia nigra (SN) and locus coeruleus (LC) is being investigated as an imaging biomarker for Parkinson’s disease (PD) using magnetization transfer contrast (MTC) magnetic resonance imaging. The MTC pulse operates in a way to suppress tissue with high macromolecular...

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Bibliographic Details
Main Authors: Yu Liu, Junchen Li, Naying He, Yongsheng Chen, Zhijia Jin, Fuhua Yan, E. Mark Haacke
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:NeuroImage
Subjects:
Neuromelanin
Magnetization transfer contrast
Quantitative MRI
Parkinson’s disease
STAGE imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811920304213

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http://www.sciencedirect.com/science/article/pii/S1053811920304213

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