VH1-69 Utilizing Antibodies Are Capable of Mediating Non-neutralizing Fc-Mediated Effector Functions Against the Transmitted/Founder gp120

VH1-69 Utilizing Antibodies Are Capable of Mediating Non-neutralizing Fc-Mediated Effector Functions Against the Transmitted/Founder gp120

Multiple antibody effector functions arise in HIV-1 infection that could be harnessed to protect against infection or clear the persistent reservoir. Here, we have investigated the genetic and functional memory B cell and antibody landscape present during early infection in six individuals infected...

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Bibliographic Details
Main Authors: S. Abigail Smith, Samantha L. Burton, William Kilembe, Shabir Lakhi, Etienne Karita, Matt Price, Susan Allen, Cynthia A. Derdeyn
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
HIV-1
gp120
VH1-69
non-neutralizing Fc-mediated effector function
neutralization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03163/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03163/full

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