PDE9A deficiency does not prevent chronic‐hypoxic pulmonary hypertension in mice

PDE9A deficiency does not prevent chronic‐hypoxic pulmonary hypertension in mice

Abstract Inhibition of cyclic guanosine monophosphate (cGMP)‐specific phosphodiesterases (PDEs) is a cornerstone of pulmonary arterial hypertension (PAH)‐specific therapy. PDE9A, expressed in the heart and lung tissue, has the highest affinity for cGMP of all known PDEs. PDE9A deficiency protects mi...

Full description

Bibliographic Details
Main Authors: Todd M. Kolb, Laura Johnston, Mahendra Damarla, David A. Kass, Paul M. Hassoun
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Physiological Reports
Subjects:
chronic hypoxia
mouse model
phosphodiesterase 9A
pulmonary hypertension
Online Access:https://doi.org/10.14814/phy2.15057

Internet

https://doi.org/10.14814/phy2.15057

Similar Items