Doxorubicin treatment modulates chemoresistance and affects the cell cycle in two canine mammary tumour cell lines

Doxorubicin treatment modulates chemoresistance and affects the cell cycle in two canine mammary tumour cell lines

Abstract Background Doxorubicin (DOX) is widely used in both human and veterinary oncology although the onset of multidrug resistance (MDR) in neoplastic cells often leads to chemotherapy failure. Better understanding of the cellular mechanisms that circumvent chemotherapy efficacy is paramount. The...

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Bibliographic Details
Main Authors: Michela Levi, Roberta Salaroli, Federico Parenti, Raffaella De Maria, Augusta Zannoni, Chiara Bernardini, Cecilia Gola, Antonio Brocco, Asia Marangio, Cinzia Benazzi, Luisa Vera Muscatello, Barbara Brunetti, Monica Forni, Giuseppe Sarli
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Veterinary Research
Subjects:
Canine mammary tumour
Cell line
Chemoresistance
Doxorubicin
P-glycoprotein
BCRP
Online Access:https://doi.org/10.1186/s12917-020-02709-5

Internet

https://doi.org/10.1186/s12917-020-02709-5

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