CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

Abstract Background Cancer associated fibroblasts (CAFs) are key stroma cells that play dominant roles in tumor progression. However, the CAFs-derived molecular determinants that regulate colorectal cancer (CRC) metastasis and chemoresistance have not been fully characterized. Methods CAFs and NFs w...

Full description

Bibliographic Details
Main Authors: J. L. Hu, W. Wang, X. L. Lan, Z. C. Zeng, Y. S. Liang, Y. R. Yan, F. Y. Song, F. F. Wang, X. H. Zhu, W. J. Liao, W. T. Liao, Y. Q. Ding, L. Liang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
Exosomes
miR-92a-3p
Stemness
Metastasis
Chemotherapy resistance
Online Access:http://link.springer.com/article/10.1186/s12943-019-1019-x

Internet

http://link.springer.com/article/10.1186/s12943-019-1019-x

Similar Items