Genotoxic Effects of Tributyltin and Triphenyltin Isothiocyanates, Cognate RXR Ligands: Comparison in Human Breast Carcinoma MCF 7 and MDA-MB-231 Cells

Genotoxic Effects of Tributyltin and Triphenyltin Isothiocyanates, Cognate RXR Ligands: Comparison in Human Breast Carcinoma MCF 7 and MDA-MB-231 Cells

The cytotoxicity of two recently synthesized triorganotin isothiocyanate derivatives, nuclear retinoid X receptor ligands, was tested and compared in estrogen-receptor-positive MCF 7 and -negative MDA-MB-231 human breast carcinoma cell lines. A 48 h MTT assay indicated that tributyltin isothiocyanat...

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Bibliographic Details
Main Authors: Luba Hunakova, Eva Horvathova, Karolina Majerova, Pavel Bobal, Jan Otevrel, Julius Brtko
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
triorganotin isothiocyanates
breast cancer
cytotoxicity
apoptosis
DNA crosslinks
Online Access:http://www.mdpi.com/1422-0067/20/5/1198

Internet

http://www.mdpi.com/1422-0067/20/5/1198

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