Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2

Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2

Selective targeting of the oxidative state, which is a tightly balanced fundamental cellular property, is an attractive strategy for developing novel anti-leukemic chemotherapeutics with potential applications in the treatment of acute myeloid leukemia (AML), a molecularly heterogeneous disease. Dim...

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Bibliographic Details
Main Authors: Rena G. Lapidus, Brandon A. Carter-Cooper, Mariola Sadowska, Eun Yong Choi, Omasiri Wonodi, Nidal Muvarak, Karthika Natarajan, Lakshmi S. Pidugu, Anil Jaiswal, Eric A. Toth, Feyruz V. Rassool, Arash Etemadi, Edward A. Sausville, Maria R. Baer, Ashkan Emadi
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Pharmaceuticals
Subjects:
dimeric naphthoquinone
acute myeloid leukemia (AML)
oxidative stress
reactive oxygen species (ROS)
Online Access:http://www.mdpi.com/1424-8247/9/1/4

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http://www.mdpi.com/1424-8247/9/1/4

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