New Pathogenesis Mechanisms and Translational Leads Identified by Multidimensional Analysis of Necrotizing Myositis in Primates

New Pathogenesis Mechanisms and Translational Leads Identified by Multidimensional Analysis of Necrotizing Myositis in Primates

Necrotizing myositis caused by Streptococcus pyogenes has high morbidity and mortality rates and relatively few successful therapeutic options. In addition, there is no licensed human S. pyogenes vaccine. To gain enhanced understanding of the molecular basis of this infection, we employed a multidim...

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Bibliographic Details
Main Authors: Priyanka Kachroo, Jesus M. Eraso, Randall J. Olsen, Luchang Zhu, Samantha L. Kubiak, Layne Pruitt, Prasanti Yerramilli, Concepcion C. Cantu, Matthew Ojeda Saavedra, Johan Pensar, Jukka Corander, Leslie Jenkins, Lillian Kao, Alejandro Granillo, Adeline R. Porter, Frank R. DeLeo, James M. Musser
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
bacterial pathogenesis
bacterial virulence
dual rna-seq
necrotizing fasciitis
pathogen-host interaction
streptococcus pyogenes
Online Access:https://doi.org/10.1128/mBio.03363-19

Internet

https://doi.org/10.1128/mBio.03363-19

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