Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
Objective. The aim of the present study was to investigate the transcriptional activity of the GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin-induced diabetes in both untreated and treated with pentoxifylline, as a non-specific blocker of TNF-α.
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| Format: | Article |
| Language: | English |
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Sciendo
2020-07-01
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| Series: | Endocrine Regulations |
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| Online Access: | https://doi.org/10.2478/enr-2020-0019 |
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Article |
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doaj-9e248494f2a24267ae224bfea6f6a0092021-09-05T21:00:49ZengSciendoEndocrine Regulations1336-03292020-07-0154316017110.2478/enr-2020-0019enr-2020-0019Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockersDegen Anna S.0Krynytska Inna Y.1Kamyshnyi Aleksandr M.2Zaporizhzhia State Medical University, Zaporizhzhia, UkraineI. Horbachevsky Ternopil National Medical University, Ternopil, UkraineZaporizhzhia State Medical University, Zaporizhzhia, UkraineObjective. The aim of the present study was to investigate the transcriptional activity of the GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin-induced diabetes in both untreated and treated with pentoxifylline, as a non-specific blocker of TNF-α.https://doi.org/10.2478/enr-2020-0019entero-insular axismrnadiabetes mellituspentoxifylline |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Degen Anna S. Krynytska Inna Y. Kamyshnyi Aleksandr M. |
| spellingShingle |
Degen Anna S. Krynytska Inna Y. Kamyshnyi Aleksandr M. Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers Endocrine Regulations entero-insular axis mrna diabetes mellitus pentoxifylline |
| author_facet |
Degen Anna S. Krynytska Inna Y. Kamyshnyi Aleksandr M. |
| author_sort |
Degen Anna S. |
| title |
Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers |
| title_short |
Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers |
| title_full |
Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers |
| title_fullStr |
Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers |
| title_full_unstemmed |
Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers |
| title_sort |
changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of tnf-α non-selective blockers |
| publisher |
Sciendo |
| series |
Endocrine Regulations |
| issn |
1336-0329 |
| publishDate |
2020-07-01 |
| description |
Objective. The aim of the present study was to investigate the transcriptional activity of the GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin-induced diabetes in both untreated and treated with pentoxifylline, as a non-specific blocker of TNF-α. |
| topic |
entero-insular axis mrna diabetes mellitus pentoxifylline |
| url |
https://doi.org/10.2478/enr-2020-0019 |
| work_keys_str_mv |
AT degenannas changesinthetranscriptionalactivityoftheenteroinsularaxisgenesinstreptozotocininduceddiabetesandaftertheadministrationoftnfanonselectiveblockers AT krynytskainnay changesinthetranscriptionalactivityoftheenteroinsularaxisgenesinstreptozotocininduceddiabetesandaftertheadministrationoftnfanonselectiveblockers AT kamyshnyialeksandrm changesinthetranscriptionalactivityoftheenteroinsularaxisgenesinstreptozotocininduceddiabetesandaftertheadministrationoftnfanonselectiveblockers |
| _version_ |
1717782186769252352 |