XBP-1s Promotes B Cell Pathogenicity in Chronic GVHD by Restraining the Activity of Regulated IRE-1α-Dependent Decay

XBP-1s Promotes B Cell Pathogenicity in Chronic GVHD by Restraining the Activity of Regulated IRE-1α-Dependent Decay

Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective therapeutic procedure to treat hematological malignancies. However, the benefit of allo-HCT is limited by a major complication, chronic graft-versus-host disease (cGVHD). Since transmembrane and secretory proteins are generated...

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Bibliographic Details
Main Authors: Hee-Jin Choi, Chih-Hang Anthony Tang, Linlu Tian, Yongxia Wu, M. Hanief Sofi, Taylor Ticer, Steven D. Schutt, Chih-Chi Andrew Hu, Xue-Zhong Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
allo-HCT
chronic GVHD
IRE-1α
XBP-1
RIDD
ER stress
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.705484/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.705484/full

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