Alzheimer’s disease brain contains tau fractions with differential prion-like activities

Alzheimer’s disease brain contains tau fractions with differential prion-like activities

Abstract Neurofibrillary tangles (NFTs) made of abnormally hyperphosphorylated tau are a hallmark of Alzheimer’s disease (AD) and related tauopathies. Regional distribution of NFTs is associated with the progression of the disease and has been proposed to be a result of prion-like propagation of mis...

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Bibliographic Details
Main Authors: Longfei Li, Ruirui Shi, Jianlan Gu, Yunn Chyn Tung, Yan Zhou, Dingwei Zhou, Ruozhen Wu, Dandan Chu, Nana Jin, Kevin Deng, Jiawei Xu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Tau pathology
Tau phosphorylation
Tau truncation
Prion-like seeding activity
Online Access:https://doi.org/10.1186/s40478-021-01127-4

Internet

https://doi.org/10.1186/s40478-021-01127-4

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