OxLDL induces macrophage γ-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis

OxLDL induces macrophage γ-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis

Oxidized LDL (oxLDL) produced a rapid depletion of intracellular glutathione (GSH) followed by an adaptive increase in J774 A.1 macrophages. OxLDL also induced a transient increase in the levels of γ-glutamylcysteine synthetase heavy subunit (γ-GCS-HS), representing the catalytic subunit of the rate...

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Bibliographic Details
Main Authors: Lijiang Shen, Alex Sevanian
Format: Article
Language:English
Published: Elsevier 2001-05-01
Series:Journal of Lipid Research
Subjects:
oxidized low density lipoprotein
γ-glutamylcysteine synthetase
reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520316448

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http://www.sciencedirect.com/science/article/pii/S0022227520316448

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