Limited survivability of unbalanced progeny of carriers of a unique t(4;19)(p15.32;p13.3): a study in multiple generations

Limited survivability of unbalanced progeny of carriers of a unique t(4;19)(p15.32;p13.3): a study in multiple generations

Abstract Background Carriership of a reciprocal chromosomal translocation (RCT) involving the short arm of chromosome 4 (4p) may result in birth of a child with Wolf-Hirschhorn syndrome (WHS) due to monosomy 4p, a priori modified by the impact of the partner chromosome imbalance. Familial transmissi...

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Bibliographic Details
Main Authors: Darinka Šumanović-Glamuzina, Bernarda Lozić, Piotr S. Iwanowski, Tatijana Zemunik, Zeljka Bilinovac, Beata Stasiewicz-Jarocka, Barbara Panasiuk, Alina T. Midro
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Molecular Cytogenetics
Subjects:
Estimation of recurrence probability
Miscarriages
Monosomy 4p15.32 → pter
Morphological phenotype
Stillbirth
Trisomy 19p13.3 → pter
Online Access:http://link.springer.com/article/10.1186/s13039-017-0330-8

Internet

http://link.springer.com/article/10.1186/s13039-017-0330-8

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