Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

Biochemical studies suggested that the antimicrobial peptide apidaecin (Api) inhibits protein synthesis by binding in the nascent peptide exit tunnel and trapping the release factor associated with a terminating ribosome. The mode of Api action in bacterial cells had remained unknown. Here genome-wi...

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Bibliographic Details
Main Authors: Kyle Mangano, Tanja Florin, Xinhao Shao, Dorota Klepacki, Irina Chelysheva, Zoya Ignatova, Yu Gao, Alexander S Mankin, Nora Vázquez-Laslop
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
ribosome
antibiotics
PrAMPs
antibacterial peptides
ribosome profiling
rescue sysytems
Online Access:https://elifesciences.org/articles/62655

Internet

https://elifesciences.org/articles/62655

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