RA190, a Proteasome Subunit ADRM1 Inhibitor, Suppresses Intrahepatic Cholangiocarcinoma by Inducing NF-KB-Mediated Cell Apoptosis

RA190, a Proteasome Subunit ADRM1 Inhibitor, Suppresses Intrahepatic Cholangiocarcinoma by Inducing NF-KB-Mediated Cell Apoptosis

Background/Aims: Effective drug treatment for intrahepatic cholangiocarcinoma (ICC) is currently lacking. Therefore, there is an urgent need for new targets and new drugs that can prolong patient survival. Recently targeting the ubiquitin proteasome pathway has become an attractive anti-cancer strat...

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Bibliographic Details
Main Authors: Guang-Yang Yu, Xuan Wang, Su-Su Zheng, Xiao-Mei Gao, Qing-An Jia, Wen-Wei Zhu, Lu Lu, Hu-Liang Jia, Jin-Hong Chen, Qiong-Zhu Dong, Ming Lu, Lun-Xiu Qin
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Intrahepatic cholangiocarcinoma (ICC)
Proteasome subunit ADRM1
RA190
Apoptosis
PDX
Online Access:https://www.karger.com/Article/FullText/490210

Internet

https://www.karger.com/Article/FullText/490210

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