Gene regulation in primates evolves under tissue-specific selection pressures.

Regulatory changes have long been hypothesized to play an important role in primate evolution. To identify adaptive regulatory changes in humans, we performed a genome-wide survey for genes in which regulation has likely evolved under natural selection. To do so, we used a multi-species microarray t...

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Bibliographic Details
Main Authors: Ran Blekhman, Alicia Oshlack, Adrien E Chabot, Gordon K Smyth, Yoav Gilad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2581600?pdf=render