New Insights on the Effect of TNF Alpha Blockade by Gene Silencing in Noise-Induced Hearing Loss

New Insights on the Effect of TNF Alpha Blockade by Gene Silencing in Noise-Induced Hearing Loss

Noise exposure represents the second most common cause of acquired sensorineural hearing loss and we observed that tumor necrosis factor α (TNFα) was involved in this context. The effect of <i>Tnfα </i>gene silencing on the expression profile related to the TNFα metabolic pathway in an e...

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Bibliographic Details
Main Authors: Janaína C. Rodrigues, André L. L. Bachi, Gleiciele A. V. Silva, Marcelo Rossi, Jonatas B. do Amaral, Karina Lezirovitz, Rubens de Brito
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
TNFα metabolic pathway
apoptosis
auditory brain response
cochlea
electrophysiological threshold
in vivo siRNA administration
Online Access:https://www.mdpi.com/1422-0067/21/8/2692

Internet

https://www.mdpi.com/1422-0067/21/8/2692

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