The Cadherin Cry1Ac Binding-Region is Necessary for the Cooperative Effect with ABCC2 Transporter Enhancing Insecticidal Activity of <i>Bacillus thuringiensis</i> Cry1Ac Toxin

The Cadherin Cry1Ac Binding-Region is Necessary for the Cooperative Effect with ABCC2 Transporter Enhancing Insecticidal Activity of <i>Bacillus thuringiensis</i> Cry1Ac Toxin

<i>Bacillus thuringiensis</i> Cry1Ac toxin binds to midgut proteins, as cadherin (CAD) and ABCC2 transporter, to form pores leading to larval death. In cell lines, co-expression of CAD and ABCC2 enhance Cry1Ac toxicity significantly, but the mechanism remains elusive. Here, we show that...

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Bibliographic Details
Main Authors: Yuemin Ma, Jianfeng Zhang, Yutao Xiao, Yanchao Yang, Chenxi Liu, Rong Peng, Yongbo Yang, Alejandra Bravo, Mario Soberón, Kaiyu Liu
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Toxins
Subjects:
<i>Helicoverpa armigera</i>
<i>Spodoptera litura</i>
cadherin
ABCC2 transporter
<i>Bacillus thuringiensis</i>
synergism
Cry1Ac
Online Access:https://www.mdpi.com/2072-6651/11/9/538

Internet

https://www.mdpi.com/2072-6651/11/9/538

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