Pharmacological Rescue of the Brain Cortex Phenotype of Tbx1 Mouse Mutants: Significance for 22q11.2 Deletion Syndrome

Pharmacological Rescue of the Brain Cortex Phenotype of Tbx1 Mouse Mutants: Significance for 22q11.2 Deletion Syndrome

ObjectivesTbx1 mutant mice are a widely used model of 22q11.2 deletion syndrome (22q11.2DS) because they manifest a broad spectrum of physical and behavioral abnormalities that is similar to that found in 22q11.2DS patients. In Tbx1 mutants, brain abnormalities include changes in cortical cytoarchit...

Full description

Bibliographic Details
Main Authors: Ilaria Favicchia, Gemma Flore, Sara Cioffi, Gabriella Lania, Antonio Baldini, Elizabeth Illingworth
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
TBX1
vitamin B12
pharmacological action
DiGeorge syndrome
Tranylcypromine
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.663598/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.663598/full

Similar Items