BEAF regulates cell-cycle genes through the controlled deposition of H3K9 methylation marks into its conserved dual-core binding sites.

Chromatin insulators/boundary elements share the ability to insulate a transgene from its chromosomal context by blocking promiscuous enhancer-promoter interactions and heterochromatin spreading. Several insulating factors target different DNA consensus sequences, defining distinct subfamilies of in...

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Bibliographic Details
Main Authors: Eldon Emberly, Roxane Blattes, Bernd Schuettengruber, Magali Hennion, Nan Jiang, Craig M Hart, Emmanuel Käs, Olivier Cuvier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2605929?pdf=render