Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge <i>Spongosorites genitrix</i>, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells

Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge <i>Spongosorites genitrix</i>, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells

Skin is an important barrier to protect the body from environmental stress. However, exposure to ultraviolet radiation (UV) and various environmental oxidative stresses can cause skin inflammation. Cyclooxygenase-2 (COX-2) is an inducible enzyme that mediates the formation of prostaglandin E<sub&...

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Bibliographic Details
Main Authors: Jiyoung Hwang, Donghwa Kim, Jae Sung Park, Hyen Joo Park, Jongheon Shin, Sang Kook Lee
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Marine Drugs
Subjects:
topsentin
<i>spongosorites genitrix</i>
uvb
skin inflammation
cox-2
mir-4485
Online Access:https://www.mdpi.com/1660-3397/18/2/87

Internet

https://www.mdpi.com/1660-3397/18/2/87

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